7-amino-1-methyl-4,5-dihydro-3,1-benzoxazepin-2(1H)-one → HCID 66830581, compound

HRID 1041737Notes

Reaction equation

HRID 1041737 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]([CH3:12])[C:10](=[O:13])[O:9][CH2:8][CH2:7][C:6]=2[CH:14]=1.Cl[C:16]1[N:21]=[C:20]([NH:22][C:23]2[CH:31]=[CH:30][CH:29]=[C:28]3[C:24]=2[CH:25]=[N:26][NH:27]3)[C:19]([Cl:32])=[CH:18][N:17]=1>>[Cl:32][C:19]1[C:20]([NH:22][C:23]2[CH:31]=[CH:30][CH:29]=[C:28]3[C:24]=2[CH:25]=[N:26][NH:27]3)=[N:21][C:16]([NH:1][C:2]2[CH:3]=[CH:4][C:5]3[N:11]([CH3:12])[C:10](=[O:13])[O:9][CH2:8][CH2:7][C:6]=3[CH:14]=2)=[N:17][CH:18]=1

Participants

3

Reactant 2

HCID 580154687-amino-1-methyl-4,5-dihydro-3,1-benzoxazepin-2(1H)-oneHCID 87330172HCID 87330172, compound

Product 1

HCID 66830581HCID 66830581, compound

Procedure

Following a procedure analogous to Example 1741e, 2-amino-5-methyl-8,9-dihydro-5H-7-oxa-5-aza-benzocyclohepten-6-one and (2,5-dichloro-pyrimidin-4-yl)-(1H-indazol-4-yl)-amine were converted to 2-[5-chloro-4-(1H-indazol-4-ylamino)-pyrimidin-2-ylamino]-5-methyl-8,9-dihydro-5H-7-oxa-5-aza-benzocyclohepten-6-one. TFA salt: 1H NMR (300 MHz, CDCl3) δ 11.91 (s, 1H), 8.04 (d, 1H), 8.00 (s, 1H), 7.54 (d, 1H), 7.42 (m, 2H), 7.29 (d, 1H), 7.21 (s, 1H), 6.87 (d, 1H), 4.33 (t, 2H), 3.32 (s, 3H), 2.66 (t, 2H); MS (m/e) 436 (M+1).

Sources & evidence

ORD record
ord-2b226ad16002418fa85cfbd478f5bf6b
Source dataset
uspto-grants-2013_10
Patent number
US08552186B2

Reaction notes

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