2-{[(Tert-butoxy)carbonyl]amino}-3-(trifluoromethoxy)benzoic acid → 2-amino-3-(trifluoromethoxy)benzoic Acid

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Reaction Steps

A solution of 2-tert-butoxycarbonylamino-3-trifluoromethoxy-benzoic acid (0.8 g, 2.5 mmol) in 30% v/v TFA/methylene chloride (50 mL) was stirred at room temperature for 1 h. Concentration of the mixture gave 2-amino-3-trifluoromethoxy-benzoic acid (0.39 g, 71%): 1H NMR (300 MHz, CDCl3) δ 7.88 (d, 1H), 7.34 (d, 1H), 6.63 (t, 1H), 6.04 (br, 2H).

Provenance & Evidence