HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Dichloro-4-nitro-thiophene-3-carboxylic acid methylamide → 4-Amino-2,5-dichloro-thiophene-3-carboxylic acid methylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Dichloro-4-nitro-thiophene-3-carboxylic acid methylamide | HCID 67264312 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-Amino-2,5-dichloro-thiophene-3-carboxylic acid methylamide | HCID 67264586 | 102.3% |
Reaction Steps
A mixture of 2,5-dichloro-4-nitro-thiophene-3-carboxylic acid methylamide (565 mg) and Raney Ni (50 mg) in ethanol was stirred under 1 atm hydrogen for 5 hours. The reaction mixture was filtered and concentrated to afford 510 mg of 4-amino-2,5-dichloro-thiophene-3-carboxylic acid methylamide: 1H NMR (300 MHz, CDCl3) δ 3.8-3.6 (bs, 3H), 3.0 (d, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08552186B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-7332962e422d469888af18b803ae9326 |
| Source note | uspto-grants-2013_10 |