HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diphosgene → 8-Fluoroisatoic anhydride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diphosgene | HCID 10426 | — |
| Reactant | 2-Amino-3-fluorobenzoic acid | HCID 586408 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 8-Fluoroisatoic anhydride | HCID 10535393 | 93.1% |
Reaction Steps
To 2-amino-3-fluoro-benzoic acid (2.3 g) in DCM (20 mL) was added trichloromethylchloroformate (3.0 g) and the mixture was stirred at rt for 16 hours. The reaction was then concentrated to provide 8-fluoro-1H-benzo[d][1,3]oxazine-2,4-dione (2.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08552186B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-5ad404a9d4a649f39b8ddf80ccd9fc53 |
| Source note | uspto-grants-2013_10 |