Sulfuric Acid → Benzene, 1-bromo-3-fluoro-4-(methylthio)-2-(trifluoromethyl)-

Temperature

45 °C

With cooling, 1.12 g (16.3 mmol) of sodium nitrite were introduced carefully into 8.00 ml of concentrated sulfuric acid. At 10-15° C., 4.00 g (15.5 mmol) of 4-bromo-2-fluoro-3-(trifluoromethyl)aniline dissolved in 30 ml of glacial acetic acid were slowly added dropwise to the clear solution, and the mixture was stirred at this temperature for 1.5 hours. 20 mg (0.31 mmol) of copper powder and 1.82 ml (20.2 mmol) of dimethyl disulfide were initially charged in 12 ml of glacial acetic acid and warmed to 45° C. The solution of the diazonium salt prepared beforehand was slowly added dropwise to this solution. After the addition had ended, the reaction mixture was stirred at 70° C. for 4 hours. The solution was then added to about 500 ml of water and extracted with CH2Cl2. The organic phase was washed with water, dilute NaHCO3 solution, dilute HCl solution and saturated NaCl solution. The organic phase was dried over Na2SO4 and evaporated to dryness. The crude product obtained was separated by column chromatography (silica gel, gradient heptane/ethyl acetate). 1-Bromo-3-fluoro-4-(methylsulfanyl)-2-(trifluoromethyl)benzene was obtained as a brown solid.

1. temperatureWith cooling
2. additionwere slowly added dropwise to the clear solution
3. additionAfter the addition
4. stirringthe reaction mixture was stirred at 70° C. for 4 hours
5. extractionextracted with CH2Cl2
6. washThe organic phase was washed with water, dilute NaHCO3 solution, dilute HCl solution and saturated NaCl solution
7. dry with materialThe organic phase was dried over Na2SO4
8. customevaporated to dryness
9. customThe crude product obtained
10. customwas separated by column chromatography (silica gel, gradient heptane/ethyl acetate)

ORD record

ord-f29dacacad5448718e17ada98fce8eee

Source dataset

uspto-grants-2013_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08557741B2