Trifluoroacetic acid → HCID 86621522, compound

Participants

Reaction Steps

A solution of 0.5 g (1.32 mmol) 1b, 12 ml dest. water and 12 ml trifluoroacetic acid was refluxed for 2 days. The reaction mixture was evaporated, dried by use of oil pump vacuum over night and treated with diethyl ether. The resulting solid was filtered, washed extensively with diethyl ether and dried by oil pump vacuum. The solid crude 1c was obtained in 98% yield (471 mg, 1.3 mmol) and crude compound 1c was used for the next step without purification.

Provenance & Evidence