Dichloromethane → HCID 86624959, compound

Participants

Reaction Steps

To a stirred solution of 3.90 g (19.8 mmol) 3a and 70 ml dichloromethane were added 32.5 g (198 mmol) methyltriflate (Aldrich) drop wisely. The reaction mixture was stirred for 2.5 days at room temperature and diethylether was added. The desired compound precipitates and the solvent was decanted. The solid was washed extensively (ten times) with large amounts of diethylether. The solid was dried by use of oil pump vacuum and purified by (C-18) RP-column chromatography (acetonitril/water-gradient 1:99 to 80:20). The desired compound 3b was obtained in 80% yield (5.72 g, 15.84 mmol).

Provenance & Evidence