Sulfuric Acid → Methyl 4-bromo-2-methylbenzoate

Participants

Reaction Conditions

Reaction Steps

Concentrated sulfuric acid (500 μL) was added to a methanol (20.0 mL) solution of 4-bromo-2-methylbenzoic acid (2.00 g, 9.30 mmol), and the mixture was stirred for 5 hours at 80° C. The reaction mixture was cooled to room temperature, subsequently a saturated aqueous solution of sodium hydrogen carbonate was added to the reaction mixture, and the mixture was subjected to extraction two times with ethyl acetate. The organic layer thus obtained was washed once with saturated brine, and was dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and thus, the title compound (2.02 g, yield: 95%) was obtained.

Provenance & Evidence