HCID 69670275, compound → HCID 69670194, compound

HRID 1041924Notes

Reaction equation

[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]([O:12][CH2:13][C:14]([NH:17][C:18](=[O:49])[C:19]1[CH:24]=[CH:23][C:22]([C:25]2[N:29]=[C:28]([CH:30]([O:33][C:34]3[CH:39]=[CH:38][C:37]([C:40]4[N:44]=[C:43]([CH:45]([CH3:47])[CH3:46])[O:42][N:41]=4)=[CH:36][CH:35]=3)[CH2:31][CH3:32])[O:27]N=2)=[CH:21][C:20]=1[F:48])(C)[CH3:15])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].F[C:51]1C=C(C2N=C(C(OC3C=CC(C4N=C(C(C)C)ON=4)=CC=3)CC)ON=2)C=CC=1C(N[C@H](C)CO)=O>>[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]([O:12][CH2:13][C@@H:14]([NH:17][C:18](=[O:49])[C:19]1[CH:24]=[CH:23][C:22]([C:25]2[N:29]=[C:28]([CH:30]([O:33][C:34]3[CH:35]=[CH:36][C:37]([C:40]4[N:44]=[C:43]([CH:45]([CH3:46])[CH3:47])[O:42][N:41]=4)=[CH:38][CH:39]=3)[CH2:31][CH3:32])[O:27][CH:51]=2)=[CH:21][C:20]=1[F:48])[CH3:15])=[O:11])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

Reactant 2

HCID 69670275HCID 69670275, compound

HCID 69670490HCID 69670490, compound

Product 1

HCID 69670194HCID 69670194, compound

Procedure

The synthesis was carried out in the same manner as in Reference Example 14, except that the compound obtained in Example 18 that will be described below (20.0 mg, 39.3 μmol) was used in place of 2-fluoro-N-[(1R)-2-hydroxy-1-methylethyl]-4-(5-{1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)benzamide. Thus, the title compound (26 mg) was obtained.

Sources & evidence

ORD record: ord-6c0e6ef726734fb381e4c074c500fc41
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08557802B2

Reaction notes

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