Acetone → Tert-butyl (1-(2-(7-(1,2-dihydroxyethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-yl)piperidin-4-yl)methylcarbamate

Participants

Reaction Steps

To tert-butyl (1-(2-(7-vinyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-yl)piperidin-4-yl)methylcarbamate (68 mg, 0.14 mmol) in acetone (2 mL) was added OsO4 (178 mg, 0.014 mmol) (2% in tBuOH) and 4-methylmorpholine N-oxide (49 mg, 0.21 mmol) (50% in H2O). The reaction was stirred for 2 hours and then concentrated. The crude material was purified by silica gel chromatography (20:1 Hexane/EtOAc) to provide the final product.

Provenance & Evidence