反应详情

温度

0 °C

(8-bromo-6-fluoroquinolin-2-yl)methanol (2 g, 7.8 mmol), DMSO (8.9 mL, 125.0 mmol), and TEA (4.9 mL, 35 mmol) were weighed into a flask and dissolved in a 10 mL of DCM, followed by cooling to 0° C. Pyridinium sulfate (4.351 g, 27.3 mmol) was added and the reaction stirred 0° C. for 1 hour. The reaction was poured onto 50 mL water and extracted with ethyl acetate. The combined organics were then dried over MgSO4, then concentrated in vacuo affording a yellow/white semi-solid, which was further purified by triturating with 20% ethyl acetate/Hexanes, affording the desired product as a tan solid (1.35 g, 68% yield).

1. extractionextracted with ethyl acetate
2. dry with materialThe combined organics were then dried over MgSO4
3. concentrationconcentrated in vacuo
4. customaffording a yellow/white semi-solid, which
5. customwas further purified
6. customby triturating with 20% ethyl acetate/Hexanes