2-Hydrazinopyridine → HCID 67233679, compound

HRID 1041987Notes

Reaction equation

HRID 1041987 reaction equation
[Br:1][C:2]1[C:11]([O:12][Si:13]([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14])=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH:20]=O)=[N:9]2)=[CH:4][CH:3]=1.[NH:22]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=1)[NH2:23]>CCO>[Br:1][C:2]1[C:11]([O:12][Si:13]([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14])=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH:20]=[N:23][NH:22][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=3)=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 786452-HydrazinopyridineHCID 86654355HCID 86654355, compound

Product 1

HCID 67233679HCID 67233679, compoundYield 80.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To the product from Step C (2.95 g, 8.05 mmol) was added EtOH (30 mL, anhydrous). To this solution was added 2-hydrazinylpyridine (0.967 g, 8.86 mmol). The mixture was stirred at ambient temperature for 24 hours. The resulting precipitate was isolated by vacuum filtration and washed with cold EtOH and then dried in vacuo to afford 2.98 g (73%) of the desired product.

Workup

  1. customThe resulting precipitate was isolated by vacuum filtration
  2. washwashed with cold EtOH
  3. customdried in vacuo

Sources & evidence

ORD record
ord-a3621d2cacee424398b26cac5f04c6f3
Source dataset
uspto-grants-2013_10
Patent number
US08557809B2

Reaction notes

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