Iodo benzene diacetate → HCID 67234839, compound

HRID 1041988Notes

Reaction equation

HRID 1041988 reaction equation
[Br:1][C:2]1[C:11]([O:12][Si:13]([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14])=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH:20]=[N:21][NH:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=3)=[N:9]2)=[CH:4][CH:3]=1.C(O)(=O)C.C(O)(=O)C.IC1C=CC=CC=1>C(Cl)Cl>[N:22]1[N:21]=[C:20]([C:8]2[CH:7]=[CH:6][C:5]3[C:10](=[C:11]([O:12][Si:13]([C:16]([CH3:19])([CH3:17])[CH3:18])([CH3:15])[CH3:14])[C:2]([Br:1])=[CH:3][CH:4]=3)[N:9]=2)[N:24]2[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=12

Participants

4

Reactant 2

HCID 12217721Iodo benzene diacetateHCID 67233679HCID 67233679, compound

Product 1

HCID 67234839HCID 67234839, compoundYield 97.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To the product from Step D (2.95 g, 6.45 mmol) was added CH2Cl2 (60 mL). Iodobenzene diacetate (2.28 g, 7.09 mmol) was added and the mixture stirred at ambient temperature overnight. The mixture was concentrated and the product purified directly by column chromatography (1 to 8% MeOH/CH2Cl2) to afford 2.87 g (88%) of the product.

Workup

  1. concentrationThe mixture was concentrated
  2. customthe product purified directly by column chromatography (1 to 8% MeOH/CH2Cl2)

Sources & evidence

ORD record
ord-c1c0fc86045a44a58e7eff1f4d171e1c
Source dataset
uspto-grants-2013_10
Patent number
US08557809B2

Reaction notes

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