Tetrahydrofuran → HCID 136337803, compound

Participants

Reaction Conditions

Reaction Steps

To the product from Step E (2.8 g, 6.15 mmol) was added THF (60 mL). The solution was cooled to 0° C. then TBAF.3H2O (2.33 g, 7.38 mmol) was added and the mixture was stirred for 1 hour. The mixture was then diluted with EtOAc (100 mL) and then washed with saturated aqueous NaHCO3 (75 mL). The layers were separated and the aqueous phase washed with EtOAc (100 mL). The combined organic phases were washed with brine and dried over Na2SO4, filtered and concentrated. The crude mixture was triturated with MeOH and the mixture was filtered and the solid was washed with Et2O (0.730 g; 35%).

Provenance & Evidence