Hydrochloric Acid → HCID 46178824, compound

Participants

Reaction Conditions

Reaction Steps

To the product from Step A (0.115 g, 0.233 mmol) was added HCl (1.17 mL, 7.00 mmol, 6.0N aqueous). The mixture was stirred at 90° C. for 45 minutes. The mixture was then cooled to ambient temperature and diluted with water (10 mL) and with CH2Cl2 (10 mL). The layers were mixed and separated and the aqueous phase was washed once more with CH2Cl2 (10 mL) and was then treated with saturated aqueous Na2CO3 until pH=10. The aqueous phase was then extracted with CH2Cl2 (3×10 mL). The combined organic phases were washed with water followed by brine and then dried over Na2SO4, filtered and concentrated to provide 0.058 g (66%) of the product >96% pure by HPLC. MS ESI (+) m/z 359.1 (M+1) detected.

Provenance & Evidence