2-Benzothiazolamine, 6-(4-morpholinyl)- → HCID 24889393, compound

HRID 1041996Notes

Reaction equation

HRID 1041996 reaction equation
[C:1]([C:5]1[O:9][N:8]=[C:7]([NH:10][C:11]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[N:21]=[C:22]4[N:26]([CH:27]=3)[C:25]3[CH:28]=[CH:29][C:30]([N:32]5[CH2:37][CH2:36]N(C)[CH2:34][CH2:33]5)=[CH:31][C:24]=3[S:23]4)=[CH:16][CH:15]=2)=[O:12])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].N1(C2C=CC3N=C(N)SC=3C=2)CC[O:42]CC1.CN1CCN(C2C=CC3N=C(N)SC=3C=2)CC1>>[C:1]([C:5]1[O:9][N:8]=[C:7]([NH:10][C:11]([NH:13][C:14]2[CH:15]=[CH:16][C:17]([C:20]3[N:21]=[C:22]4[N:26]([CH:27]=3)[C:25]3[CH:28]=[CH:29][C:30]([N:32]5[CH2:33][CH2:34][O:42][CH2:36][CH2:37]5)=[CH:31][C:24]=3[S:23]4)=[CH:18][CH:19]=2)=[O:12])[CH:6]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 3

HCID 9371972-Benzothiazolamine, 6-(4-morpholinyl)-HCID 24889213HCID 24889213, compoundHCID 39104846HCID 39104846, compound

Product 1

HCID 24889393HCID 24889393, compound

Procedure

1-(5-tert-butyl-isoxazol-3-yl)-3-{4-[7-(4-methyl-piperazin-1-yl)-benzo[d]imidazo[2,1-b]thiazol-2-yl]-phenyl}-urea. was prepared in a manner similar to Steps A-D, except that in Step A, 6-morpholin-4-ylbenzothiazol-2-ylamine was substituted with 6-(4-methylpiperazin-1-yl)-1,3-benzothiazol-2-amine. 1H NMR (CDCl3) δ 9.3 (br, 1H), 7.84 (d and s, 3H), 7.59 (br, 1H), 7.56 (d, 2H), 7.49 (d, 1H), 7.20 (d, 1H), 7.05 (dd, 1H), 5.86 (s, 1H), 3.250 (t, 4H), 2.62 (t, 4H), 2.38 (s, 3H),1.36 (s, 9H). [Compound A7]

Sources & evidence

ORD record
ord-5e487bc0034e416ea822e5230892ed2c
Source dataset
uspto-grants-2013_10
Patent number
US08557810B2

Reaction notes

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