反应详情

43 g of the product from 1d were dissolved in 300 ml of diethyl ether. A solution of 3.1 g of lithium borohydride in 300 ml of diethyl ether was added dropwise thereto. The mixture was stirred for 6 h and the reaction was stopped by cautious addition of 300 ml of a saturated potassium bicarbonate solution. The phases were separated and the organic phase was washed with 250 ml of a saturated sodium chloride solution. The organic phase was dried with sodium sulfate, and the solvent was removed in vacuo. The residue was chromatographed on silica gel.

1. customThe phases were separated
2. washthe organic phase was washed with 250 ml of a saturated sodium chloride solution
3. dry with materialThe organic phase was dried with sodium sulfate
4. customthe solvent was removed in vacuo
5. customThe residue was chromatographed on silica gel