HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1042034Generated: October 26, 2026
Piperidine → 5-morpholino-3-(piperidin-1-yl)-7H-thieno[3,2-b]pyran-7-one
https://huagongshe.com/reaction/1042034
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Ethyl 2-oxocyclohexanecarboxylate | HCID 95543 | — |
| Reactant | 3-Bromo-5-(morpholin-4-yl)-7H-thieno[3,2-b]pyran-7-one | HCID 44181178 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Product | 5-morpholino-3-(piperidin-1-yl)-7H-thieno[3,2-b]pyran-7-one | HCID 44180856 | — |
Reaction Steps
A 0.5 mL microwave vial was charged with a magnetic stirring bar, 3-bromo-5-morpholino-7H-thieno[3,2-b]pyran-7-one (103) (50 mg, 158 μmol), cesium carbonate (103 mg, 316 mop, copper (1) iodide (3 mg, 31 μmol), ethyl 2-oxocyclohexanecarboxylate (10 μL, 63 μmol), and piperidine (200 μL). The reaction mixture was sealed, and the reaction mixture was magnetically stirred and heated via microwave irradiation to 150° C. for 15 minutes to give 5-morpholino-3-(piperidin-1-yl)-7H-thieno[3,2-b]pyran-7-one (71).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08557807B2 |
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| Source dataset | uspto-grants-2013_10 |
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| ORD ID | ord-47073b3f8a5d433cb2dbfbdce3c2d8a2 |
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| Source note | uspto-grants-2013_10 |
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