Morpholine → HCID 44180963, compound

Participants

Reaction Conditions

Reaction Steps

A 2 mL conical microwave vial was charged with a magnetic stirring bar, 3-(4-chlorophenyl)-5-morpholino-7H-thieno[3,2-b]pyran-7-one (17) (80 mg, 230 μmol), sodium tert-butoxide (31 mg, 322 μmol), tris(dibenzylideneacetone)dipalladium(0) (3 mg, 3.5 μmol), 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl (8.8 mg, 21 μmol), dimethoxyethane (0.5 mL), and morpholine (24 μL, 276 μmol). The reaction mixture was sealed, and the reaction mixture was magnetically stirred and heated via microwave irradiation to 150° C. for 15 minutes to give 5-morpholino-3-(4-morpholinophenyl)-7H-thieno[3,2-b]pyran-7-one (72).

Provenance & Evidence