Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Butanol | HCID 263 | — |
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | Tri-tert-butylphosphine tetrafluoroborate | HCID 2734635 | — |
| Reactant | HCID 59609979 | HCID 59609979 | — |
| Catalyst | Molybdenum carbonyl (Mo(CO)6) | HCID 98885 | — |
| Catalyst | trans-Bis(acetato)bis[2-[bis(2-methylphenyl)phosphino]benzyl]dipalladium(II) | HCID 11104995 | — |
| Product | HCID 44180966 | HCID 44180966 | — |
Reaction Steps
A 2 mL microwave vial was charged with a magnetic stirring bar, 3-(3-chlorophenyl)-5-morpholino-7H-thieno[3,2-b]pyran-7-one (85) (80 mg, 230 μmol), imidazole (47 mg, 690 μmol), molybdenum hexacarbonyl (60 mg, 230 umol), trans-di(μ-acetato)bis[o-(di-o-tolyl-phosphino)benzyl]dipalladium (II) (6.5 mg, 6.9 μmol), tri-tert-butylphosphonium tetrafluoroborate (4.0 mg, 13.9 μmol), tetrahydrofuran (500 μL), n-butanol (63 μL, 690 μmol), and 1,8-diazabicyclo[5.4.0]undec-7-ene (103 μL, 690 μmol). The vial was immediately sealed, and the reaction mixture was magnetically stirred and heated via microwave irradiation to 170° C. for 15 minutes in a microwave reactor to give butyl 3-(5-morpholino-7-oxo-7H-thieno[3,2-b]pyran-3-yl)benzoate (75).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08557807B2 |
|---|
| Source dataset | uspto-grants-2013_10 |
|---|
| ORD ID | ord-3087360e35fe46ed9bb2089b093cfc92 |
|---|
| Source note | uspto-grants-2013_10 |
|---|
