Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Iodobenzene | HCID 11575 | — |
| Reactant | Potassium Fluoride | HCID 522689 | — |
| Reactant | 3-Bromo-5-(morpholin-4-yl)-7H-thieno[3,2-b]pyran-7-one | HCID 44181178 | — |
| Catalyst | Silver Nitrate | HCID 24470 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 44180967 | HCID 44180967 | — |
Reaction Steps
A 2 mL conical microwave vial was charged with a magnetic stirring bar, 3-bromo-5-morpholino-7H-thieno[3,2-b]pyran-7-one (103) (50 mg, 158 μmol), phenyl iodide (27 mg, 132 μmol), potassium fluoride (11.5 mg, 198 μmol), silver nitrate (34 mg, 198 μmol), anhydrous dimethyl sulfoxide (1 mL), and dichlorobis(triphenylphosphine)palladium (II) (4.6 mg, 6.6 mop. The reaction mixture was sealed, and the reaction mixture was magnetically stirred and heated under microwave irradiation to 120° C. for 15 minutes to give 3-bromo-5-morpholino-2-phenyl-7H-thieno[3,2-b]pyran-7-one (76).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08557807B2 |
|---|
| Source dataset | uspto-grants-2013_10 |
|---|
| ORD ID | ord-62e4db09ba1d459c9d01bda7014e23e9 |
|---|
| Source note | uspto-grants-2013_10 |
|---|
