1-(2,3-Dihydro-1,1,2,3,3-pentamethyl-1H-inden-5-yl)ethan-1-one → 4-(1,1,2,3,3-Pentamethyl-indan-5-yl)-pyrimidine

Participants

Reaction Conditions

Reaction Steps

A 5 L reaction vessel was charged with 1,1,2,3,3-pentamethyl-5-indanyl methyl ketone (460 g, 2.0 mol) (commercially available at IFF), formamidine acetate (675 g, 6.4 mol), and butanol (1.0 L). The reaction mixture was heated to 120° C. for 10 hours and then cooled to 25° C. The reaction mixture was washed twice with brine (1 L) and purified by vacuum distillation to afford 4-(2,3-dihydro-1,1,2,3,3-pentamethyl-1H-inden-5-yl)-pyrimidine (200 g) having a boiling point of 153° C. at a pressure of 2.0 mmHg.

Provenance & Evidence