HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-chloro-N-(1-ethynylcyclohexyl)benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Chlorobenzenesulphonyl chloride | HCID 17909 | — |
| Reactant | 1-Ethynylcyclohexylamine | HCID 121691 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-chloro-N-(1-ethynylcyclohexyl)benzenesulfonamide | HCID 86624997 | 94.4% |
Reaction Steps
To a solution of 1-ethynylcyclohexanamine (40 mg, 0.32 mmol) in CH2Cl2, was added triethylamine (68 mL, 0.48 mmol), followed by 3-chlorobenzenesulfonyl chloride (68.2 mg, 0.32 mmol). After 30 min, the mixture was partitioned between ethyl acetate and 3N aq. HCl. The organic layer was washed with sat. NaHCO3, brine, dried over Na2SO4, concentrated in vacuuo to give the title compound as a white solid (90 mg, 93% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08557828B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-2fd02a35fe1947fda4d21a1d596838a9 |
| Source note | uspto-grants-2013_10 |