Benzyl Bromide → 2-(Benzyloxy)-4-fluoro-1-nitrobenzene

Participants

Reaction Steps

To a mixture of 5-fluoro-2-nitrophenol (50.0 g), potassium carbonate (44.0 g) and N,N-dimethylformamide (150 mL) was added under ice-cooling benzyl bromide (59.9 g), and the mixture was stirred at room temperature for 15 hr. The reaction solution was concentrated under reduced pressure, water was added, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure. The obtained solid was washed with hexane to give the title compound (77.1 g, yield 98%) as pale-yellow crystals.

Provenance & Evidence