Hexane → HCID 86661830, compound

Participants

Reaction Steps

To a solution of 5-({6-[(methylsulfonyl)methyl]pyridin-3-yl}oxy)-7-(tetrahydro-2H-pyran-4-yloxy)-1H-indole-2-carboxamide (3.0 g) in tetrahydrofuran (20 mL) was added a Lawesson's reagent (3.0 g), and the mixture was stirred with heating under reflux for 1 hr. The reaction mixture was cooled, and concentrated under reduced pressure. The obtained crude product was subjected to silica gel column chromatography (ethyl acetate:hexane=0:100 to 100:0, volume ratio) to give the title compound (2.26 g, yield 73%) as a yellow amorphous solid.

Provenance & Evidence