Sodium Hydroxide → HCID 66726156, compound

Participants

Reaction Steps

To a solution of ethyl 5-{[6-(methylsulfonyl)pyridin-3-yl]oxy}-1H-indole-2-carboxylate (5.6 g) in ethanol (100 mL) and tetrahydrofuran (100 mL) was added 1N aqueous sodium hydroxide solution (31.1 mL), and the mixture was stirred at room temperature for 15 hr. The reaction mixture was concentrated, 1N hydrochloric acid (32 mL) was added, and the precipitated crystals were filtered and concentrated under reduced pressure to give the title compound (5.2 g, yield 100%) as white crystals.

Provenance & Evidence