Hexane → HCID 86661834, compound

Participants

Reaction Steps

To a solution of 5-{[6-(methylsulfonyl)pyridin-3-yl]oxy}-1H-indole-2-carboxamide (4.5 g) in tetrahydrofuran (100 mL) was added a Lawesson's reagent (6 g), and the mixture was stirred with heating under reflux for 1 hr. The reaction mixture was cooled, and concentrated under reduced pressure. The obtained crude product was subjected to basic silica gel column chromatography (ethyl acetate:hexane=0:100 to 100:0, volume ratio) to give the title compound (3.7 g, yield 78%) as yellow powder.

Provenance & Evidence