4-Methylbenzaldehyde → 6-Methylisoquinoline

Temperature

65 °C

Aminoacetaldehyde dimethyl acetal (8.83 mL, 81.1 mmol) was added over 1 min to a stirred solution of p-tolualdehyde (9.88 mL, 81.1 mmol) in chloroform (150 mL) at 22° C. An exotherm was noted. The reaction was heated to reflux (65° C.) and half the solvent was removed (azeotropically to remove water). The heat was removed and the yellow solution was cooled to r.t. NMR showed the imine was formed smoothly, however, a trace of aldehyde was observed. The yellow solution was diluted with chloroform to bring the volume back to ˜100 mL, cooled to −3° C. and ethyl chloroformate (7.99 mL, 81.1 mmol) was added dropwise over 5 min followed by triethyl phosphite (17.4 mL, 97.3 mmol) over 10 minutes. The clear yellow solution was then allowed to warm to RT. A reflux condenser added to reaction vessel. After 23 h, titanium tetrachloride (35.6 mL, 324 mmol) was added very slowly (strong exotherm and white fumes observed) and the reaction began to gently reflux (50° C.). Color changed from yellow to dark red to dark brown. Once addition was complete, the dark brown solution was heated to reflux (52° C.) for 10.5 h. After allowing to cool to RT overnight, the dark brown solution was poured onto ice (filled a 2 L beaker with approximately 1 L of ice), the organic layer was separated off, and the aqueous layer was washed with DCM (2×100 mL). The aqueous layer (now orange in color) was poured into a solution of potassium sodium tartrate tetrahydrate (183 g, 648 mmol) in water (300 mL), basified to pH 9 with 28-30% ammonium hydroxide (a white ppt crashed out) and then extracted with DCM (3×200 mL). The organic layer was separated, dried over sodium sulfate, filtered and the solvent was evaporated in vacuo to yield 6-methylisoquinoline (9.02 g, 78% yield) as a light tan amorphous solid. Found MS (ESI, pos. ion) m/z: 144.1 [M+H]+

1. temperatureThe reaction was heated
2. customwas removed (azeotropically
3. customto remove water)
4. customThe heat was removed
5. temperaturethe yellow solution was cooled to r.t
6. customwas formed smoothly
7. temperaturecooled to −3° C.
8. temperatureto warm to RT
9. additionA reflux condenser added to reaction vessel
10. temperatureto gently reflux (50° C.)
11. additionOnce addition
12. temperaturethe dark brown solution was heated
13. temperatureto reflux (52° C.) for 10.5 h
14. temperatureto cool to RT overnight
15. additionthe dark brown solution was poured onto ice (
16. customwas separated off
17. washthe aqueous layer was washed with DCM (2×100 mL)
18. extractionthen extracted with DCM (3×200 mL)
19. customThe organic layer was separated
20. dry with materialdried over sodium sulfate
21. filtrationfiltered
22. customthe solvent was evaporated in vacuo

ORD record

ord-9efd7eb0e43f4b26856f2b49d8c8c431

Source dataset

uspto-grants-2013_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08557830B2