反应详情

LiBH4 (5.10 g, 0.23 mmol) was added to a solution of 2-methoxy-3-methyl-benzoic acid methyl ester (8.46 g, 47.00 mmol) in Et2O at 0° C. The reaction mixture was stirred for 5 minutes, MeOH (9.50 mL, 0.23 mmol) was added in a dropwise fashion. The reaction mixture was then stirred for 30 minutes, and was quenched into 1N NaOH. The resulting solution was extracted with Et2O (3×200 mL) and the combined organic phases were washed with brine (1×150 mL), dried over MgSO4 and concentrated to afford the title compound.

1. stirringThe reaction mixture was then stirred for 30 minutes
2. customwas quenched into 1N NaOH
3. extractionThe resulting solution was extracted with Et2O (3×200 mL)
4. washthe combined organic phases were washed with brine (1×150 mL)
5. dry with materialdried over MgSO4
6. concentrationconcentrated