Hydrochloric Acid → HCID 67095439, compound

Participants

Reaction Steps

To 225 mg (E)-N-(2-amino-phenyl)-3-{1-[4-(1-methyl-1H-pyrazol-4-yl)-benzenesulfonyl]-1H-pyrrol-3-yl}-acrylamide (0.50 mmol) in 20 ml of warm methanol a solution (3.13 mL, 0.5 mmol) of HCl in methanol (to 4 mL 4N HClaqueous methanol was added to a final of 100 mL=0.16 mmol/mL) was added dropwise. Immediately, a yellowish oil separated. By adding diethyl ether (10 mL) the full separation was done. The resulting solid was dried overnight. Yield: 248 mg (102%); yellowish solid; MP: 150-164° C., sinter. The compound contained 0.91 HCl/Mol.

Provenance & Evidence