反应详情

3,7-dimethyloctanoic acid was dissolved in thionyl chloride (10 ml) and treated in water bath for 3 hours to distill off excess thionyl chloride. Ethanol (30 ml) was added to chloride of 3,7-dimethyloctanoic acid and refluxed in water bath for 2 hours. After cooling, the reaction mixture was added to 1N HCl (80 ml) to be acidic and distributed with EtOAc. The distributed liquid was purified with column chromatography (developing solvent: C6H14-EtOAc (3:1)) after concentration, and the 3,7-dimethyloctanoic acid ethyl ester shown in the following was isolated. 3,7-dimethyloctanoic acid was obtained by contact reduction of geranic acid.

1. distillationto distill off excess thionyl chloride
2. additionEthanol (30 ml) was added to chloride of 3,7-dimethyloctanoic acid
3. temperaturerefluxed in water bath for 2 hours
4. temperatureAfter cooling
5. additionthe reaction mixture was added to 1N HCl (80 ml)
6. customThe distributed liquid was purified with column chromatography (developing solvent: C6H14-EtOAc (3:1))
7. concentrationafter concentration
8. customfollowing was isolated