反应详情

温度

130 °C

A 100 mL reaction flask is charged with 2-isopropyl-cyclohexanone (10 g, 0.07 mol), formamidine acetate (40 g, 0.4 mol), and butanol (50 mL). The reaction mixture is heated to 130° C. and stirred for 24 hours. The crude mass is washed once with aqueous sulfuric acid (10%, 100 mL) followed by twice with brine (30 mL). Butanol is recovered by roto-evaporation. The crude product is further purified with liquid chromatography (Biotage® system) and then crystallized. Product 8-isopropyl-5,6,7,8-tetrahydro-quinazoline (˜5 g) is obtained.

1. customA 100 mL reaction flask
2. washThe crude mass is washed once with aqueous sulfuric acid (10%, 100 mL)
3. customButanol is recovered by roto-evaporation
4. customThe crude product is further purified with liquid chromatography (Biotage® system)
5. customcrystallized