Methyl Acrylate → HCID 66855655, compound

Participants

Reaction Steps

In a 100 ml flask, 4-iodobenzotrifluoride (1 g, 3.68 mmol) was dissolved in 10 ml DMF, and Pd(OAc)2 (165 mg, 0.2 eq), K2CO3 (2.54 g, 5.0 eq), KOAc (1.8 g, 5.0 eq), norbornylene (692 mg, 1.0 eq), methyl acrylate (0.33 ml, 1.0 eq), and iodopropane (3.75 g, 6.0 eq) were added stepwisely at room temperature. The resulting reaction mixture was stirred for 3 days. After the completion of the reaction, the Na2S2O3 solution was poured into the reaction mixture, which was stirred for 30 minutes, extracted with EtOAc 50 ml (3 times), and dried with anh. MgSO4. The organic layer was filtered, concentrated in vacuo, and purified with column chromatography (Hexane: EtOAc=8:1) to give the title compound (0.343 g, 30%).

Provenance & Evidence