HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → N-methoxy-N-methyl-2-ethoxy-4-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | N,O-Dimethylhydroxylamine | HCID 14232 | — |
| Reactant | 2-Ethoxy-4-(trifluoromethyl)benzoic acid | HCID 22494327 | — |
| Catalyst | 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride | HCID 2734059 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | N-methoxy-N-methyl-2-ethoxy-4-trifluoromethyl-benzamide | HCID 86649957 | 73.3% |
Reaction Steps
2-Ethoxy-4-trifluoromethyl-benzoic acid (1.20 g, 5.12 mmol) was reacted with N,O-dimethylhydroxy amine (609 mg), NMM (0.95 ml) and DMTMM (1.47 mg) as described above to give the title compound (1.04 g, 73%) after column chromatography (Hex/EtOAc=5/1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08557872B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-e87f3b968edf49f1abde6e58e27189d8 |
| Source note | uspto-grants-2013_10 |