HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → 3-(2-Ethoxy-4-trifluoromethyl-phenyl)-acrylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester | HCID 17453 | — |
| Reactant | 2-Ethoxy-4-(trifluoromethyl)benzaldehyde | HCID 22494338 | — |
| Product | 3-(2-Ethoxy-4-trifluoromethyl-phenyl)-acrylic acid methyl ester | HCID 66855439 | 52% |
Reaction Steps
2-Ethoxy-4-trifluoromethyl-benzaldehyde (729 mg, 3.34 mmol) was reacted with methyl (triphenylphosphoranylidene)acetate (1.45 g, 4.34 mmol) at 110° C. overnight as described above to yield title compound (476.5 mg, 52%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08557872B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-3a728d5f68f541cd90fc4e13b4e1c7ee |
| Source note | uspto-grants-2013_10 |