HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetaldehyde → 2-ethylamino-N-methoxy-N-methyl-4-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetaldehyde | HCID 177 | — |
| Reactant | Sodiumacetoxyborohydride | HCID 23670382 | — |
| Reactant | 2-amino-N-methoxy-N-methyl-4-trifluoromethyl-benzamide | HCID 86649959 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-ethylamino-N-methoxy-N-methyl-4-trifluoromethyl-benzamide | HCID 86649960 | 17.7% |
Reaction Steps
2-Amino-N-methoxy-N-methyl-4-trifluoromethyl-benzamide (482 mg, 1.94 mmol) was reacted with acetaldehyde (0.12 ml, 2.14 mmol) and sodium acetoxyborohydride (892 mg, 4.20 mmol) in CH2Cl2 at room temperature as described above to yield title compound (95 mg, 17%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08557872B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-fae254677d8342f2a1a0837a508b8cb8 |
| Source note | uspto-grants-2013_10 |