HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl acetate hexane → 2-Ethylamino-4-trifluoromethyl-benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | 2-ethylamino-N-methoxy-N-methyl-4-trifluoromethyl-benzamide | HCID 86649960 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Ethylamino-4-trifluoromethyl-benzaldehyde | HCID 86649961 | 29.5% |
Reaction Steps
2-Ethylamino-N-methoxy-N-methyl-4-trifluoromethyl-benzamide (95 mg, 0.343 mmol) was reacted with LAH in THF at −40° C. for 1.5 hrs as described above to yield title compound (22 mg, 29%) after column chromatography (hexane/ethylacetate=20/1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08557872B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-94292db96b1244739583925b718f0f3e |
| Source note | uspto-grants-2013_10 |