HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → 3-(4-Fluoro-2-hydroxy-phenyl)-acrylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester | HCID 17453 | — |
| Reactant | 4-Fluoro-2-hydroxybenzaldehyde | HCID 2779268 | — |
| Product | 3-(4-Fluoro-2-hydroxy-phenyl)-acrylic acid methyl ester | HCID 66857693 | 85.6% |
Reaction Steps
2-Hydroxy-4-fluoro-benzaldehyde (306 mg, 1.99 mmol) was reacted with methyl (triphenylphosphoranylidene)acetate (681 g, 2.044 mmol) at 110° C. overnight as described above to yield title compound (334 mg, 85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08557872B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-824353f505814fd88893169e7f90b00a |
| Source note | uspto-grants-2013_10 |