HCID 66855891, compound → HCID 44159134, compound

HRID 1042506Notes

Reaction equation

HRID 1042506 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C@H:14]([NH:16][C:17](=[O:34])[CH:18]=[CH:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][C:21]=2[NH:30][CH2:31][CH2:32][CH3:33])[CH3:15])[CH:5]=[C:6]([F:13])[C:7]=1[NH:8][S:9]([CH3:12])(=[O:11])=[O:10]>[Pd]>[F:1][C:2]1[CH:3]=[C:4]([C@H:14]([NH:16][C:17](=[O:34])[CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]([F:27])([F:28])[F:29])=[CH:22][C:21]=2[NH:30][CH2:31][CH2:32][CH3:33])[CH3:15])[CH:5]=[C:6]([F:13])[C:7]=1[NH:8][S:9]([CH3:12])(=[O:11])=[O:10]

Participants

3

Reactant 1

HCID 66855891HCID 66855891, compound

Product 1

HCID 44159134HCID 44159134, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

(R)—N-[1-(3,5-Difluoro-4-methanesulfonylamino-phenyl)-ethyl]-3-(2-propylamino-4-trifluoromethyl-phenyl)-acrylamide (12 mg) was reduced with Pd/C (15 mg) under hydrogen atmosphere to yield title compound (7 mg, 60%).

Sources & evidence

ORD record
ord-dfb6b5caaf204cb981b09bd7f15c876f
Source dataset
uspto-grants-2013_10
Patent number
US08557872B2

Reaction notes

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