N-(3,5-Difluoro-4-methanesulfonylamino-benzyl)-3-(2-propylamino-4-trifluoromethyl-phenyl)-acrylamide → N-(3,5-Difluoro-4-methanesulfonylamino-benzyl)-3-(2-propylamino-4-trifluoromethyl-phenyl)-propionamide

HRID 1042507Notes

Reaction equation

HRID 1042507 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:25]=[C:26]([F:33])[C:27]=1[NH:28][S:29]([CH3:32])(=[O:31])=[O:30])[CH2:5][NH:6][C:7](=[O:24])[CH:8]=[CH:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][C:11]=1[NH:20][CH2:21][CH2:22][CH3:23]>[Pd]>[F:1][C:2]1[CH:3]=[C:4]([CH:25]=[C:26]([F:33])[C:27]=1[NH:28][S:29]([CH3:32])(=[O:30])=[O:31])[CH2:5][NH:6][C:7](=[O:24])[CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:17])[F:18])=[CH:12][C:11]=1[NH:20][CH2:21][CH2:22][CH3:23]

Participants

3

Reactant 1

HCID 66856230N-(3,5-Difluoro-4-methanesulfonylamino-benzyl)-3-(2-propylamino-4-trifluoromethyl-phenyl)-acrylamide

Product 1

HCID 66856627N-(3,5-Difluoro-4-methanesulfonylamino-benzyl)-3-(2-propylamino-4-trifluoromethyl-phenyl)-propionamideYield 59.3%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

N-(3,5-Difluoro-4-methanesulfonylamino-benzyl)-3-(2-propylamino-4-trifluoromethyl-phenyl)-acrylamide (20 mg, 0.041 mmol) was reduced with Pd/C under hydrogen atmosphere to yield title compound (12 mg, 59%).

Sources & evidence

ORD record
ord-d309e128e24b46c9acd6383ad8b34c78
Source dataset
uspto-grants-2013_10
Patent number
US08557872B2

Reaction notes

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