HCID 58238507, compound → HCID 58238506, compound

Participants

Reaction Steps

A solution of 5 (0.74 g, 1.58 mmol) in methanol (25 mL) was treated with 20% palladium on activated carbon (50% wet, 0.07 g) and was hydrogenated at 30 psi in a Parr shaker for 2 hr. The catalyst was filtered out and washed with methanol. The filtrate was stripped and the residue was chromatographed on silica (40 g) with 1% ethyl acetate in hexane (3 L). The relevant fractions were stripped and the residue was triturated with ethanol and dried in a vacuum oven at 65° C. to produce pure B1 (0.49 g, 81%).

Provenance & Evidence