HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → [2-(1H-imidazol-1-yl)ethyl]methylamine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Methanesulfonate | HCID 85257 | — |
| Reactant | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| Product | [2-(1H-imidazol-1-yl)ethyl]methylamine dihydrochloride | HCID 6483896 | — |
Reaction Steps
1-[2-(N-methylamino)ethyl]imidazole was synthesized from the mesylate of 2-(N-Boc-N-methylamono)ethanol, which was allowed to react with imidazole in the presence of LiHMDS. The starting material was prepared by selective protection of amino group with Boc-anhydride in the presence of Al2O3 according to the procedure described in literature (Yadar, V. K.; Ganesh Babu, K. J. Org. Chem. 2004, 69, 577-580).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08557979B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-0413cc7e7aab4307827a0801629b8fc0 |
| Source note | uspto-grants-2013_10 |