Imidazole → HCID 11510103, compound

Participants

Reaction Steps

A mixture of 2-bromo-7-acetoxy-3-(3,4,5-trimethoxybenzoyl)-6-methoxy-benzo[b]furan (30 mg, 0.063 mmol) and imidazole (60 mg, 0.88 mmol) in a mixture of toluene:triethylamine (3 mL: 2 drops) was refluxed for 4 hours (tlc). Solvent was distilled under vacuum and the crude residue was purified by PTLC (eluent=ethyl-acetate: 1% triethylamine) to give the title compound as a yellow solid; (8 mg, 30%); 1H NMR (300 MHz, CDCl3) δ 8.24 (bs, 1H), 7.52 (b, 1H), 7.19 (b, 1H), 7.06 (s, 2H, benzoyl Hs), 6.99 (d, 1H, J=8.60 Hz), 6.93 (d, 1H, J=8.66 Hz), 3.96 (s, 3H, OMe), 3.91 (s, 3H, OMe), 3.76 (s, 6H, 2×OMe).

Provenance & Evidence