Imidazole → HCID 11575461, compound

HRID 1042595Notes

Reaction equation

HRID 1042595 reaction equation
[N:1]1([C:6]2[O:10][C:9]3[C:11]([OH:17])=[C:12]([O:15][CH3:16])[CH:13]=[CH:14][C:8]=3[C:7]=2[C:18](=[O:31])[C:19]2[CH:24]=[C:23]([O:25][CH3:26])[C:22]([O:27][CH3:28])=[C:21]([O:29][CH3:30])[CH:20]=2)[CH:5]=[CH:4][N:3]=C1.[NH:32]1C=CN=N1.N1C=CN=C1>>[N:1]1([C:6]2[O:10][C:9]3[C:11]([OH:17])=[C:12]([O:15][CH3:16])[CH:13]=[CH:14][C:8]=3[C:7]=2[C:18](=[O:31])[C:19]2[CH:20]=[C:21]([O:29][CH3:30])[C:22]([O:27][CH3:28])=[C:23]([O:25][CH3:26])[CH:24]=2)[CH:5]=[CH:4][N:3]=[N:32]1

Participants

4

Reactant 3

HCID 795ImidazoleHCID 11510103HCID 11510103, compoundHCID 178418936HCID 178418936, compound

Product 1

HCID 11575461HCID 11575461, compound

Procedure

This material was prepared according to the procedure outlined above for 2-(N-imidazolyl)-7-hydroxy-3-(3,4,5-trimethoxybenzoyl)-6-methoxy-benzo[b]furan (entry 27, Table 1), above, except the 1,2,3-triazole was used as the nucleophile in place of imidazole. 1H NMR (300 MHz, CDCl3) δ 8.47 (d, 1H, J=1.21 Hz), 7.75 (d, 1H, J=1.20 Hz), 7.27 (d, 1H, J=8.60 Hz), 7.18 (d, 1H, J=8.66 Hz), 7.05 (s, 2H, benzoyl Hs), 3.94 (s, 3H, OMe), 3.74 (s, 6H, 2×OMe), 3.73 (s, 3H, OMe).

Workup

  1. customThis material was prepared

Sources & evidence

ORD record
ord-331247de2e554ce7b1633d67de39069c
Source dataset
uspto-grants-2013_10
Patent number
US08557982B2

Reaction notes

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