HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminopyridine → HCID 718006, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminopyridine | HCID 10439 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Methoxy-3-nitrobenzoyl chloride | HCID 12375463 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 718006 | HCID 718006 | — |
Reaction Steps
4-methoxy-3-nitrobenzoyl chloride (1.08 g, 0.005 mol), 2-aminopyridine (0.94 g, 0.01 mol) and DIPEA (1.8 mL, 0.01 mol) were allowed to stir in dichloromethane (10 mL) for 48 hours to form 4-methoxy-3-nitro-N-(pyridin-2-yl)benzamide. Intermediate was purified via silica column chromatography using 0 to 100% ethyl acetate in hexane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08557996B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-dd6d74feb5a64a189daf660813a97e63 |
| Source note | uspto-grants-2013_10 |