3-(Trifluoromethyl)aniline → 3-Bromo-4-fluoro-N-(3-(trifluoromethyl)phenyl)benzamide

HRID 1042731Notes

Reaction equation

HRID 1042731 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][CH:9]=1)[NH2:6].[Br:12][C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][C:21]=1[F:22])[C:16](Cl)=[O:17]>>[Br:12][C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][C:21]=1[F:22])[C:16]([NH:6][C:5]1[CH:7]=[CH:8][CH:9]=[C:3]([C:2]([F:10])([F:11])[F:1])[CH:4]=1)=[O:17]

Participants

3

Reactant 2

HCID 73753-(Trifluoromethyl)anilineHCID 695983-Bromo-4-fluorobenzoyl chloride

Product 1

HCID 594280183-Bromo-4-fluoro-N-(3-(trifluoromethyl)phenyl)benzamide

Procedure

3-Bromo-4-fluoro-N-(3-(trifluoromethyl)phenyl)benzamide was synthesized from 3-trifluoromethylaniline and 3-bromo-4-fluorobenzoyl chloride according to the procedure described in Example 183, affording the title compound as a white solid. MS (M−H+) 360.0; Calculated for C14H8BrF4NO: 361.

Sources & evidence

ORD record
ord-21baf3c04dbf4935b24dafd88295dcaa
Source dataset
uspto-grants-2013_10
Patent number
US08557996B2

Reaction notes

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