Diethyl (ethoxymethylene)malonate → Diethyl 2-((5-bromopyridin-3-ylamino)methylene)malonate

Participants

Reaction Steps

To a 500 mL RBF containing 5-bromopyridin-3-amine (60.0 g, 347 mmol) was added diethyl 2-(ethoxymethylene)malonate (71.0 mL, 354 mmol) and 121 mL of toluene. The reaction mixture was heated to reflux for 3 h. The reaction mixture was allowed to cool RT overnight, and the resulting precipitate was collected by filtration and dried to give the desired product as a white crystalline solid.

Provenance & Evidence