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In a RBF fitted with a reflux condenser, 7-bromo-4-hydroxy-1,5-naphthyridine-3-carboxylic acid (1 g, 4 mmol) was added in portions over 10 minutes to stirred refluxing quinoline (50 mL), and the resulting mixture was refluxed for 1 h. The mixture was cooled and diluted with acetone. The precipitate was filtered, washed with water and dried to give 0.8 g of a grey-brown powder. The product was reprecipitated from aq. NaOH with glacial acetic acid to give a white solid.

1. customIn a RBF fitted with a reflux condenser
2. temperaturethe resulting mixture was refluxed for 1 h
3. temperatureThe mixture was cooled
4. filtrationThe precipitate was filtered
5. washwashed with water
6. customdried