HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-4-(trimethylstannyl)pyridin-2(1H)-one → 4-(4-(4-(7-Methoxy-1,5-naphthyridin-4-ylthio)phenylamino)phthalazin-1-yl)-1-methylpyridin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-4-(trimethylstannyl)pyridin-2(1H)-one | HCID 67317779 | — |
| Reactant | 4-chloro-N-(4-(7-methoxy-1,5-naphthyridin-4-ylthio)phenyl)phthalazin-1-amine | HCID 86628664 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-(4-(4-(7-Methoxy-1,5-naphthyridin-4-ylthio)phenylamino)phthalazin-1-yl)-1-methylpyridin-2(1H)-one | HCID 59427299 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
4-Chloro-N-(4-(7-methoxy-1,5-naphthyridin-4-ylthio)phenyl)phthalazin-1-amine (148 mg, 331 μmol), 1-methyl-4-(trimethylstannyl)pyridin-2(1H)-one (90 mg, 331 μmol), and the Pd catalyst were added to toluene and heated to 100° C. for 2 h. The mixture was concentrated and purified by silica gel chromatography using 0 to 30% MeOH in ethyl acetate. MS: M+H+=519.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08557816B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-6dda5bf9ed4b44b7a0642d52c29a6288 |
| Source note | uspto-grants-2013_10 |