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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1042944Generated: October 30, 2026

Nitric Acid → 1,4-Dinitro-1H-imidazole

https://huagongshe.com/reaction/1042944

Reaction equation

Participants

RoleNameHCIDCharge
ReactantNitric AcidHCID 944—
ReactantHCID 178526856HCID 178526856—
SolventAcetic AcidHCID 176—
SolventAcetic AnhydrideHCID 7918—
Product1,4-Dinitro-1H-imidazoleHCID 516949652.1%

Reaction Steps

In NON-PATENT DOCUMENT 5, 100 mass % nitric acid is added dropwise to 4-nitroimidazole in glacial acetic acid and acetic anhydride is further added dropwise thereto to perform nitration reaction, and then the reaction solution is added into crushed ice and 1,4-dinitroimidazole is produced at a yield of 52.1% by performing filtration, washing and vacuum drying.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08558005B2
Source datasetuspto-grants-2013_10
ORD IDord-d34885cab3144fe48544906bf4969c01
Source noteuspto-grants-2013_10